Research
Research in our group is focused on three major inter-related areas:
Using genomic data to understand allosteric regulation in signaling proteins
We are interested in using the wealth of evolutionary information embedded in genome sequences to understand the allosteric modes of regulation in signaling proteins. We are particularly focusing on two major families — protein kinases and phosphatases — that have evolved numerous allosteric mechanisms to respond to diverse activation and regulatory signals.
Modeling protein kinase and phosphatase interactions in signaling pathways
We are interested in understanding how protein kinases and phosphatases interact with each other and with other cellular components in signaling pathways. To accomplish this goal, we intend to use a combination of computational and experimental approaches.
Cancer genomics and personalized therapeutics
We are interested in developing new tools and approaches for identifying cancer driver mutations in cancer genomes. We are particularly focusing on the protein kinase gene family, which has been sequenced from many different cancer types. We are also investigating how cancer driver mutations in protein kinases contribute to drug resistance.