Welcome to the ESBG Lab


We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse family of enzymes that propagate cellular signals through the controlled phosphorylation of protein and small molecule substrates. We are using a combination of computational and experimental approaches to understand how natural sequence variation contributes to functional variation in protein kinases, and how non-natural variation contributes to disease.

See the research page to learn more about our ongoing projects.

Latest news

Eric Talevich secures a post-doctoral position at UCSF

August 1, 2013

Eric Talevich graduated this summer and has started his post-doctoral stint at UCSF. Congratulations Eric!!

New publication in PNAS identifies a hidden structural mechanism in protein kinases

December 31, 2012

Krishnadev Oruganty, Nakul Talathi, Zachary Wood, and Dr. Natarajan Kannan have published a new research article in the PNAS journal titled "Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases." This paper reveals a novel conformational switch involved in protein kinases.

Dr. Kannan wins the NSF CAREER Award

June 5, 2012

Dr. Kannan has received the NSF CAREER Award to study the evolutionary design principles of protein kinases.

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