Welcome to the ESBG Lab


We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein kinases, a large and diverse family of enzymes that propagate cellular signals through the controlled phosphorylation of protein and small molecule substrates. We are using a combination of computational and experimental approaches to understand how natural sequence variation contributes to functional variation in protein kinases, and how non-natural variation contributes to disease.

See the research page to learn more about our ongoing projects.

Latest news

New Publication in PLoS Genetics

Feb 29, 2016

Smita Mohanty, Krishnadev Oruganty, Annie Kwon, Dominic P. Byrne, Samantha Ferries, Zheng Ruan, Laura E. Hanold, Samiksha Katiyar, Eileen J. Kennedy, Patrick A. Eyers, and Dr. Natarajan Kannan have published a new research article in the PLOS Genetics journal titled "Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization ". This article demonstrates the role of distal variations in protein evolution and disease.

Our Lab Receives Grant!

August 1, 2015

Dr. Natarajan Kannan has been awarded a 5 year NIH award to identify causative disease mutations in signaling proteins. Congratulations!!

Tuan Nguyen receives the Goldwater Scholarship

June 27, 2014

Tuan Nguyen has been named a 2014 Barry M. Goldwater Scholar. Congratulations to Tuan for earning this prestigious award!

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