Publications

Publications

  1. An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases

    Brady O'Boyle, Wayland Yeung, Jason D. Lu, Samiksha Katiyar, Tomer M. Yaron-Barir, Jared L. Johnson, Lewis C. Cantley, Natarajan Kannan

    Science Signaling, 2025

    ArticleDOI

  2. Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms

    George N. Bendzunas, Dominic P. Byrne, Safal Shrestha, Leonard A. Daly, Sally O. Oswald, Samiksha Katiyar, Aarya Venkat, Wayland Yeung, Claire E. Eyers, Patrick A. Eyers, Natarajan Kannan

    eLife, 2025

    ArticleDOI

  3. CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

    James Holder, Jennifer A. Miles, Matthew Batchelor, Harrison Popple, Martin Walko, Wayland Yeung, Natarajan Kannan, Andrew J. Wilson, Richard Bayliss, Fanni Gergely

    The EMBO Journal, 2024

    ArticleDOI

  4. Cancer-associated mutations in protein kinase C theta are loss-of-function

    Stefanie J. Hodapp, Nathan Gravel, Natarajan Kannan, Alexandra C. Newton

    Biochemical Journal, 2024

    ArticleDOI

  5. Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways

    Safal Shrestha , Rahil Taujale , Samiksha Katiyar , Natarajan Kannan

    NPJ Systems Biology and Applications, 2024

    ArticleDOI

  6. Using explainable machine learning to uncover the kinase–substrate interaction landscape

    Zhongliang Zhou , Wayland Yeung, Saber Soleymani, Nathan Gravel , Mariah Salcedo , Sheng Li, Natarajan Kannan

    Bioinformatics, 2024

    ArticleDOI

  7. Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park, Nathan Gravel, Saber Soleymani, Rayna Carter, Kennady Boyd, Sarah Keuning, Zheng Ruan, Wei Lü, Natarajan Kannan

    eLife(Reviewed Preprint), 2024

    DOI

  8. Informatic challenges and advances in illuminating the druggable proteome

    Rahil Taujale, Nathan Gravel, Zhongliang Zhou, Wayland Yeung, Krystof Kochut, Natarajan Kannan

    Drug Discovery Today, 2024

    ArticleDOI

  9. Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs

    Mitchell H. Omar, Dominic P. Byrne, Samiksha Shrestha, Tharindumala M. Lakey, Kyung S. Lee, Stephanie M. Lauer, Kimberly B. Collins, Luke A. Daly, Claire E. Eyers, Geoffrey S. Baird, Shao-En Ong, Natarajan Kannan, Patrick A. Eyers, John D. Scott

    Science Advances, 2024

    ArticleDOI

  10. Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases

    Venkat, A., Watterson, G., Byrne, D.P., Boyle, B.O., Shrestha, S., Gravel, N., Fairweather, E.E., Daly, L.A., Bunn, C., Yeung, W., Aggarwal, I, Katiyar, S., Eyers, C.E., Eyers, P.A., and Kannan, N.

    elife, 2023

    ArticleDOI

  11. Predicting protein and pathway associations for understudied dark kinases using pattern-constrained knowledge graph embedding

    Salcedo, M.V., Gravel, N., Keshavarzi, A., Huang, L.C., Kochut, K.J. and Kannan, N.

    PeerJ, 2023

    ArticleDOI

  12. Prevalence and Homology of the Pneumococcal Serine-Rich Repeat Protein at the Global Scale

    Aceil, J., Venkat, A., Pan, E., Kannan, N. and Avci, F.

    Microbiology Spectrum, 2023

    ArticleDOI

  13. Structural and biochemical insight into a modular β-1, 4-galactan synthase in plants

    Prabhakar, P.K., Pereira, J.H., Taujale, R., Shao, W., Bharadwaj, V.S., Chapla, D., Yang, J.Y., Bomble, Y.J., Moremen, K.W., Kannan, N., Hammel, M., Adams, P.D., Scheller, H.V., and Urbanowicz, B.R.

    Nature Plants, 2023

    ArticleDOI

  14. Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions

    Zhou, Z., Yeung, W., Gravel, N., Salcedo, M., Soleymani, S., Li, S. and Kannan, N.

    Bioinformatics, 2023

    ArticleDOI

  15. Evolutionary and cellular analysis of the ‘dark’pseudokinase PSKH2

    Byrne, D.P., Shrestha, S., Daly, L.A., Marensi, V., Ramakrishnan, K., Eyers, C.E., Kannan, N. and Eyers, P.A.

    Biochemical Journal, 2023

    ArticleDOI

  16. Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings

    Yeung, W., Zhou, Z., Li, S. and Kannan, N.

    Briefings in Bioinformatics, 2023

    ArticleDOI

  17. Tree visualizations of protein sequence embedding space enable improved functional clustering of diverse protein superfamilies

    Yeung, W., Zhou, Z., Mathew, L., Gravel, N., Taujale, R., O’Boyle, B., Salcedo, M., Venkat, A., Lanzilotta, W., Li, S. and Kannan, N.

    Briefings in Bioinformatics, 2023

    ArticleDOI

  18. Protein kinase inhibitor selectivity “hinges” on evolution

    Shrestha, S., Bendzunas, G. and Kannan, N.

    Structure, 2022

    ArticleDOI

  19. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition

    Pilo, C.A., Baffi, T.R., Kornev, A.P., Kunkel, M.T., Malfavon, M., Chen, D.H., Rossitto, L.A., Chen, D.X., Huang, L.C., Longman, C. and Kannan, N.

    Science signaling, 2022

    ArticleDOI

  20. Modularity of the hydrophobic core and evolution of functional diversity in fold A glycosyltransferases.

    Venkat, A., Tehrani, D., Taujale, R., Yeung, W., Gravel, N., Moremen, K.W. and Kannan, N.

    The Journal of biological chemistry, 2022

    ArticleDOI

  21. Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters.

    Berger, B.M., Yeung, W., Goyal, A., Zhou, Z., Hildebrandt, E.R., Kannan, N. and Schmidt, W.K.

    PloS one, 2022

    ArticleDOI

  22. Computational tools and resources for pseudokinase research.

    O'Boyle, B., Shrestha, S., Kochut, K., Eyers, P.A. and Kannan, N.

    Methods in Enzymology, 2022

    ArticleDOI

  23. GTXplorer: A portal to navigate and visualize the evolutionary information encoded in fold A glycosyltransferases.

    Taujale, R., Soleymani, S., Priyadarshi, A., Venkat, A., Yeung, W., Kochut, K. J., and Kannan N.

    Glycobiology, 2021

    ArticleDOI

  24. Evolution of Functional Diversity in the Holozoan Tyrosine Kinome.

    Yeung, W., Kwon, A., Taujale, R., Bunn, C., Venkat, A., and Kannan N.

    Molecular Biology and Evolution, 2021

    ArticleDOI

  25. Mapping the glycosyltransferase fold landscape using interpretable deep learning.

    Taujale, R., Zhou, Z., Yeung, W., Moremen, K. W., Li, S., and Kannan N

    Nature Communications, 2021

    ArticleDOI

  26. KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.

    Huang, L.C., Taujale, R., Gravel, N., Venkat, A., Yeung, W., Byrne, D.P., Eyers, P.A. and Kannan, N.

    BMC Bioinformatics, 2021

    ArticleDOI

  27. Peters plus syndrome mutations affect the function and stability of human beta 1,3-glucosyltransferase.

    Zhang, A., Venkat, A., Taujale, R., Mull, J. L., Ito, A., Kannan N., and Haltiwanger, R. S.

    Journal of Biological Chemistry

    ArticleDOI

  28. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.

    Garnish, S.E., Meng, Y., Koide, A., Sandow, J.J., Denbaum, E., Jacobsen, A.V., Yeung, W., Samson, A.L., Horne, C.R., ... Kannan, N. ... and Young, S.N.

    Nature Communications, 2021

    ArticleDOI

  29. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

    Baffi, T. R., Lorden, G., Wozniak, J. M., Feichtner, A., Yeung, W., Kornev, A. P., ... Kannan N., ... Newton, A. C.

    Science Signaling, 2021

    ArticleDOI

  30. Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.

    Oliver, M.R., Horne, C.R., Shrestha, S., Keown, J.R., Liang, L.Y., Young, S.N., Sandow, J.J., Webb, A.I., Goldstone, D.C., Lucet, I.S. and Kannan, N.

    Nature Communications, 2021

    ArticleDOI

  31. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix

    Wu J, Yang J, Kannan N, Madhusudhan, Xuong NH, Ten Eyck LF, Taylor SS.

    Protein Sci. 2005

    ArticleDOI

  32. Task Splitting and Prompt Engineering for Cypher Query Generation in Domain-Specific Knowledge Graphs

    Saber Soleymani, Nathan Gravel, Krzysztof Kochut, Natarajan Kannan

    bioRxiv (Preprint), 2025

    DOI

  33. Identification of side-chain clusters in protein structures by a graph spectral method

    Kannan N, Vishveshwara S.

    J. Mol. Biol. 1999; 292(2):441-64

    Article

  34. Aromatic clusters: a determinant of thermal stability in thermophilic proteins

    Kannan N, Vishveshwara S.

    Protein Eng. 2000; 13(11):753-61

    Article

  35. Logos for amino-acid preferences in different backbone packing density regions of protein structural classes

    Kannan N, Schneider TD, Vishveshwara S.

    Acta Crystallog. D 2000; 59(9):1156-65

    Article

  36. Stabilizing interactions in the dimer interface of alpha-subunit in E. coli RNA polymerase: A graph spectral and point mutation study

    Kannan N, Chander P, Ghosh P, Vishveshwara S, Chatterji D.

    Protein Sci. 2001; 10(1):46-54

    Article

  37. Clusters in alpha/beta barrel proteins: implications for protein structure and folding: a graph theoretical approach

    Kannan N, Selvaraj S, Gromiha MM, Vishveshwara S.

    Proteins 2001; 43(2):103-12

    Article

  38. Analysis of homodimeric protein interfaces using graph spectral method

    Brinda KV, Kannan N, Vishveshwara S.

    Protein Eng. 2002; 15(4):265-77

    Article

  39. Protein structure: Insights from graph theory

    Vishveshwara S, Brinda KV, Kannan N.

    J. of Theor. and Comp. Chemistry 2002; 1(1):187-212

  40. Ran's C-terminal basic patch and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras and Ran GTPases

    Neuwald AF, Kannan N, Poleksic A, Hata N, Lu J.

    Genome Res. 2002; 13(4):673-692

    Article

  41. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources

    Andersen JN, Kannan N, Gergel J, Neuwald AF, Tonks NK.

    Methods 2005; 35(1):90-114

    Article

  42. Structural features associated with functional specificity of CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK and CK2alpha

    Kannan N, Neuwald AF.

    Protein Sci. 2004; 13(8):100-128

    Article

  43. Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?

    Kannan N, Neuwald AF.

    J. Mol. Biol. 2005; 351:956-972

    Article

  44. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

    Kannan N, Haste N, Taylor SS, Neuwald AF.

    PNAS 2007; 104(4):1272-7

    Article

  45. Structural and functional diversity of the microbial kinome

    Kannan N, Taylor SS, Yufeng Z, Venter C, Manning G.

    PLoS Biol. 2007; 5(3):e83

    Article

  46. Evolution of allostery in the cyclic nucleotide binding module

    Kannan N, Wu J, Anand G, Shibu Y, Venter C, Taylor SS.

    Genome Biol. 2007; 8(12):R264

    Article

  47. Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for Drug Design

    Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N.

    Biochemica Biophysica Acta 2008; 1784(1):16-26

    Article

  48. Analogous regulatory sites in ZAP-70 tyrosine kinase and AGC kinases

    Kannan N, Neuwald AF, Taylor SS.

    Biochemica Biophysica Acta 2008; 1784(1):27-32

    Article

  49. Rethinking pseudokinases

    Kannan N, Taylor SS..

    Cell 2008; 133(2):204-5

    Article

  50. Congenital disease SNPs target lineage specific structural elements in protein kinases

    Torkamani A, Kannan N, Taylor SS, Schork NJ.

    PNAS 2008; 105(26):9011-6

    ArticleDOI

  51. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail

    Gould CM, Kannan N, Taylor SS, Newton AC.

    J. Biol Chem. 2009; 284:4921-4935

    Article

  52. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1

    Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS.

    Protein Sci. 2009; 18(7):1486-97

    Article

  53. Comparative surface geometry of the protein kinase family

    Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS.

    Protein Sci. 2009; 18(10):2016-26

    Article

  54. Co-conserved features associated with cis regulation of ErbB tyrosine kinases

    Mirza A, Mustafa M, Talevich E, Kannan N.

    PLoS One 2010; 5(12):e14310

    ArticleDOI

  55. Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: A molecular dynamics study

    Mustafa M, Mirza A, Kannan N.

    Proteins 2011; 79(1):99-114

    ArticleDOI

  56. Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

    Talevich E, Mirza A, Kannan N.

    BMC Evol. Biol. 2011; 11:321

    ArticleDOI

  57. ProKinO: An Ontology for Integrative Analysis of Protein Kinases in Cancer

    Gosal G, Kochut KJ, Kannan N.

    PLoS One 2011; 6(12):e28782

    ArticleDOI

  58. An evolutionary perspective on the kinome of malaria parasites

    Talevich E, Tobin AB, Kannan N, Doerig C.

    Philos. Trans. B 2012; 367(1602):2607-18

    ArticleDOI

  59. Design principles underpinning the regulatory diversity of protein kinases

    Oruganty K, Kannan N.

    Philos. Trans. B 2012; 367(1602):2517-28

    ArticleDOI

  60. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.

    Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC.

    J BIol Chem. 2012: 287(16):13262-78

    ArticleDOI

  61. Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases

    Oruganty K, Talathi NS, Wood ZA, Kannan N.

    PNAS 2012; 110(3):924-929

    ArticleDOI

  62. Evolutionary variation and adaptation in a conserved protein kinase allosteric network: Implications for inhibitor design

    Oruganty K, Kannan N.

    Biochim. Biophys. Acta 2013; 1834(7):1322-1329

    ArticleDOI

  63. Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors

    Talevich E, Kannan N.

    BMC Evol. Biol. 2013; 13:117

    ArticleDOI

  64. Global Analysis of Protein Expression and Phosphorylation of Three Stages of Plasmodium falciparum Intraerythrocytic Development

    Pease BN, Huttlin EL, Jedrychowski MP, Talevich E, Harmon J, Dillman T, Kannan N, Doerig C, Chakrabarti R, Gygi SP, Chakrabarti D.

    J Proteome Res. 2013; 12(9):4028-4045

    ArticleDOI

  65. Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

    Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP.

    PLoS Biol 2013; 11(10):

    ArticleDOI

  66. Prediction and Prioritization of Rare Oncogenic Mutations in the Cancer Kinome Using Novel Features and Multiple Classifiers

    U M, Talevich E, Katiyar S, Rasheed K, Kannan N.

    PLoS Comput Biol. 2014; 10(4):

    ArticleDOI

  67. Kinase Regulation by Hydrophobic Spine Assembly in Cancer

    Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS.

    Mol Cell Biol. 2014; 35(1):

    ArticleDOI

  68. Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis

    Stefely JA, Reidenbach AG, Ulbrich A, Oruganty K, Floyd BJ, Jochem A, Saunders JM, Johnson IE, Minogue CE, Wrobel RL, Barber GE, Lee D, Li S, Kannan N, Coon JJ, Bingman CA, Pagliarini DJ.

    Mol Cell. 2014; 57(1):

    ArticleDOI

  69. The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

    Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA.

    Biochem J. 2015; 467(1):

    ArticleDOI

  70. Going for broke: Targeting the human cancer pseudokinome

    MBailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA.

    Biochem J. 2015; 467(2):195-211

    ArticleDOI

  71. ProKinO: a unified resource for mining the cancer kinome

    McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor SS, Kochut K, Kannan N.

    Hum Mutat. 2015; 36(2):175-186

    ArticleDOI

  72. Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics

    Hanold LE, Oruganty K, Ton NT, Beedle AM, Kannan N, Kennedy EJ.

    PLoS One 2015; 10(3):

    ArticleDOI

  73. Co-Conserved MAPK Features Couple D-Domain Docking Groove to Distal Allosteric Sites via the C-Terminal Flanking Tail

    Nguyen T, Ruan Z, Oruganty K, Kannan N.

    PLoS One 2015; 10(3):

    ArticleDOI

  74. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design

    Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N.

    Biochim Biophys Acta. 2015; 1854:

    ArticleDOI

  75. Integration of signaling in the kinome: Architecture and regulation of the alphaC Helix

    Taylor SS, Shaw AS, Kannan N, Kornev AP.

    Biochim Biophys Acta. 2015; 1854:1567-1574

    ArticleDOI

  76. Dialing in EGFR Signaling

    Kennedy EJ, Kannan N.

    Chem Biol. 2015; 22(6):687-688

    ArticleDOI

  77. Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor (EGFR) Kinase

    Ruan Z, Kannan N.

    Biochemistry 2015; 54(27):4216-4225

    ArticleDOI

  78. The Ty1 Retrotransposon Restriction Factor p22 Targets Gag

    Tucker JM, Larango ME, Wachsmuth LP, Kannan N, Garfinkel DJ.

    PLoS Genetics 2015; 11(10):

    ArticleDOI

  79. Creating Biomedical Ontologies Using mOntage

    Dastgheib S, McSkimming DI, Kannan N, Kochut K.

    Data Integration in the Life Sciences (Book Chapter) 2015; 9162:

    ArticleDOI

  80. Identification and classification of small molecule kinases: insights into substrate recognition and specificity

    Oruganty K, Talevich E, Neuwald AF, Kannan N.

    BMC Evolutionary Biology 2016; 16(7):

    ArticleDOI

  81. Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

    Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

    PLoS Genet. 2016; 12(2):

    ArticleDOI

  82. Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity

    Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJ, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ.

    Mol Cell. 2016; 63(4):608-620

    ArticleDOI

  83. KinView: a visual comparative sequence analysis tool for integrated kinome research

    McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyersd PA, Kannan N.

    Mol Biosyst. 2016; 12(12):3651-3665

    ArticleDOI

  84. Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

    Eyers PA, Keeshan K, Kannan N.

    Trends Cell Biol. 2016

    ArticleDOI

  85. Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase

    Ruan Z, Katiyar S, Kannan N.

    Biochemistry 2016; 22:22-32

    ArticleDOI

  86. RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia

    Hattori A, McSkimming D, Kannan N, Ito T

    Leuk Res. 2017; 54:47-54

    ArticleDOI

  87. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

    Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison AS, Ito T

    Nature 2017; 545(7655):500-504

    ArticleDOI

  88. Classifying kinase conformations using a machine learning approach

    McSkimming D, Rasheed K, Kannan N

    BMC Bioinformatics 2017; 18:86

    ArticleDOI

  89. The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena

    Jiang YY, Maier W, Baumeister R, Minevich G, Joachimiak E, Ruan Z, Kannan N, Clarke D, Frankel J, Gaertig J

    Genetics 2017; 206(2):873-888

    ArticleDOI

  90. Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation

    Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ

    Bioorg Med Chem. 2017; Available online

    ArticleDOI

  91. Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

    Rahman K, Mandalasi M, Zhao P, Sheikh MO, Taujale R, Kim HW, van der Wel H, Matta K, Kannan N, Glushka JN, Wells L, West CM.

    The Journal of biological chemistry. 2017; 292(45):18644-18659

    ArticleDOI

  92. Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution

    A Kwon, M John, Z Ruan, N Kannan

    Journal of Biological Chemistry 293 (14), 5102-5116

    ArticleDOI

  93. Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations

    Z Ruan, N Kannan

    Proceedings of the National Academy of Sciences, 201803152

    ArticleDOI

  94. Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

    Sam A. Jamieson1, Zheng Ruan, Abigail E. Burgess, Jack R. Curry, Hamish D. McMillan, Jodi L. Brewster, Anita K. Dunbier, Alison D. Axtman, Natarajan Kannan, and Peter D. Mace

    Science Signaling, 2018, 11(549)

    ArticleDOI

  95. Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

    Daniel M. Foulkes, Dominic P. Byrne, Wayland Yeung, Safal Shrestha, Fiona P. Bailey, Samantha Ferries, Claire E. Eyers, Karen Keeshan, Carrow Wells, David H. Drewry, William J. Zuercher, Natarajan Kannan, and Patrick A. Eyers

    Science Signaling, 2018, 11(549)

    ArticleDOI

  96. Tracing the origin and evolution of pseudokinases across the tree of life

    Annie Kwon, Steven Scott, Rahil Taujale, Wayland Yeung, Krys J. Kochut, Patrick A. Eyers, and Natarajan Kannan

    Science Signaling, 2019, 12(578)

    ArticleDOI

  97. Cataloguing the dead: breathing new life into pseudokinase research

    Safal Shrestha, Dominic P. Byrne, John A. Harris, Natarajan Kannan, Patrick A. Eyers

    The FEBS Journal, 2020

    ArticleDOI

  98. Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease

    Wayland Yeung, Zheng Ruan, Natarajan Kannan

    IUBMB Life, 2020

    ArticleDOI

  99. Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

    Rahil Taujale, Aarya Venkat, Liang-Chin Huang, Zhongliang Zhou, Wayland Yeung, Khaled M Rasheed, Sheng Li, Arthur S Edison, Kelley W Moremen, Natarajan Kannan

    eLife, 2020

    ArticleDOI

  100. A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

    Safal Shrestha, Samiksha Katiyar, Carlos E. Sanz-Rodriguez, Nolan R. Kemppinen, Hyun W. Kim, Renuka Kadirvelraj, Charalampos Panagos, Neda Keyhaninejad, Maxwell Colonna, Pradeep Chopra, Dominic P. Byrne, Geert J. Boons, Esther van der Knaap, Patrick A. Eyers, Arthur S. Edison, Zachary A. Wood, and Natarajan Kannan

    Science Signaling, 2020

    DOI
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