Predicting the functional impact of cancer mutations in protein kinases
Large scale cancer genome sequencing studies are beginning to reveal the mutational profiles of the 518 protein kinase genes encoded in the human genome from many different cancer types. A detailed understanding of the structural and functional impact of these mutations can potentially lead to new therapies for cancer. We are integrating and analyzing diverse forms of protein kinase data to identify key causative mutations in the cancer kinome. We are using selected receptor tyrosine kinases as our experimental system to predict and test the impact of cancer mutations. We are also developing a computational framework for rapid and consistent annotations of protein kinase mutations identified in cancer genome sequencing studies.