Recent publications

1. Evolutionary variation and adaptation in a conserved protein kinase allosteric network: Implications for inhibitor design.
   Oruganty K, Kannan N.
   Biochim. Biophys. Acta 2013; (in press):
   (PubMed | DOI)
2. Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.
   Oruganty K, Talathi NS, Wood ZA, Kannan N.
   PNAS 2012; 110(3):924-929
   (PubMed | DOI)
3. Design principles underpinning the regulatory diversity of protein kinases.
   Oruganty K, Kannan N.
   Philos. Trans. B 2012; 367(1602):2517-28
   (PubMed | DOI)
4. An evolutionary perspective on the kinome of malaria parasites.
   Talevich E, Tobin AB, Kannan N, Doerig C.
   Philos. Trans. B 2012; 367(1602):2607-18
   (PubMed | DOI)
5. ProKinO: An Ontology for Integrative Analysis of Protein Kinases in Cancer
   Gosal G, Kochut KJ, Kannan N.
   PLoS One 2011; 6(12):e28782
   (PubMed | DOI)
6. Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.
   Talevich E, Mirza A, Kannan N.
   BMC Evol. Biol. 2011; 11:321
   (PubMed | DOI)
7. Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: A molecular dynamics study.
   Mustafa M, Mirza A, Kannan N.
   Proteins 2011; 79(1):99-114
   (PubMed | DOI)
8. Co-conserved features associated with cis regulation of ErbB tyrosine kinases.
   Mirza A, Mustafa M, Talevich E, Kannan N.
   PLoS One 2010; 5(12):e14310
   (PubMed | DOI)
9. Comparative surface geometry of the protein kinase family.
   Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS.
   Protein Sci. 2009; 18(10):2016-26
   (PubMed)
10. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1.
    Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS.
    Protein Sci. 2009; 18(7):1486-97
    (PubMed)
11. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
    Gould CM, Kannan N, Taylor SS, Newton AC.
    J. Biol Chem. 2009; 284:4921-4935
    (PubMed)
12. Congenital disease SNPs target lineage specific structural elements in protein kinases.
    Torkamani A, Kannan N, Taylor SS, Schork NJ.
    PNAS 2008; 105(26):9011-6
    (PubMed | DOI)
13. Rethinking pseudokinases.
    Kannan N, Taylor SS..
    Cell 2008; 133(2):204-5
    (PubMed)
14. Analogous regulatory sites in ZAP-70 tyrosine kinase and AGC kinases.
    Kannan N, Neuwald AF, Taylor SS.
    Biochemica Biophysica Acta 2008; 1784(1):27-32
    (PubMed)
15. Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for Drug Design.
    Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N.
    Biochemica Biophysica Acta 2008; 1784(1):16-26
    (PubMed)
16. Evolution of allostery in the cyclic nucleotide binding module.
    Kannan N, Wu J, Anand G, Shibu Y, Venter C, Taylor SS.
    Genome Biol. 2007; 8(12):R264
    (PubMed)
17. Structural and functional diversity of the microbial kinome.
    Kannan N, Taylor SS, Yufeng Z, Venter C, Manning G.
    PLoS Biol. 2007; 5(3):e83
    (PubMed)
18. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
    Kannan N, Haste N, Taylor SS, Neuwald AF.
    PNAS 2007; 104(4):1272-7
    (PubMed)
19. Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?
    Kannan N, Neuwald AF.
    J. Mol. Biol. 2005; 351:956-972
    (PubMed)
20. Structural features associated with functional specificity of CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK and CK2alpha.
    Kannan N, Neuwald AF.
    Protein Sci. 2004; 13(8):100-128
    (PubMed)
21. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
    Wu J, Yang J, Kannan N, Madhusudhan, Xuong NH, Ten Eyck LF, Taylor SS.
    Protein Sci. 2005; 14(11):2871-9
    (PubMed)
22. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources.
    Andersen JN, Kannan N, Gergel J, Neuwald AF, Tonks NK.
    Methods 2005; 35(1):90-114
    (PubMed)
23. Ran's C-terminal basic patch and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras and Ran GTPases.
    Neuwald AF, Kannan N, Poleksic A, Hata N, Lu J.
    Genome Res. 2002; 13(4):673-692
    (PubMed)
24. Protein structure: Insights from graph theory.
    Vishveshwara S, Brinda KV, Kannan N.
    J. of Theor. and Comp. Chemistry 2002; 1(1):187-212
    (PDF)
25. Analysis of homodimeric protein interfaces using graph spectral method.
    Brinda KV, Kannan N, Vishveshwara S.
    Protein Eng. 2002; 15(4):265-77
    (PubMed)
26. Clusters in alpha/beta barrel proteins: implications for protein structure and folding: a graph theoretical approach.
    Kannan N, Selvaraj S, Gromiha MM, Vishveshwara S.
    Proteins 2001; 43(2):103-12
    (PubMed)
27. Stabilizing interactions in the dimer interface of alpha-subunit in E. coli RNA polymerase: A graph spectral and point mutation study.
    Kannan N, Chander P, Ghosh P, Vishveshwara S, Chatterji D.
    Protein Sci. 2001; 10(1):46-54
    (PubMed)
28. Logos for amino-acid preferences in different backbone packing density regions of protein structural classes.
    Kannan N, Schneider TD, Vishveshwara S.
    Acta Crystallog. D 2000; 59(9):1156-65
    (PubMed)
29. Aromatic clusters: a determinant of thermal stability in thermophilic proteins.
    Kannan N, Vishveshwara S.
    Protein Eng. 2000; 13(11):753-61
    (PubMed)
30. Identification of side-chain clusters in protein structures by a graph spectral method.
    Kannan N, Vishveshwara S.
    J. Mol. Biol. 1999; 292(2):441-64
    (PubMed)