Recent publications

  1. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.
    J. Biol Chem.. (2009): 284:4921-4935
    Gould CM, Kannan N, Taylor SS, Newton AC.
    ( PubMed )
  2. Congenital disease SNPs target lineage specific structural elements in protein kinases.
    PNAS. (2008): 105(26):9011-6
    Torkamani A, Kannan N, Taylor SS, Schork NJ.
    ( PubMed )
  3. Rethinking pseudokinases.
    Cell. (2008): 133(2):205-5
    Kannan N, Taylor SS.
    ( PubMed )
  4. Analogous regulatory sites in ZAP-70 tyrosine kinase and AGC kinases.
    Biochemica Biophysica Acta. (2008): 1784(1):27-32
    Kannan N, Neuwald AF, Taylor SS.
    ( PubMed )
  5. Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for Drug Design.
    Biochemica Biophysica Acta (2008): 1784(1):16-26
    Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N.
    ( PubMed )
  6. Evolution of allostery in the cyclic nucleotide binding module.
    Genome Biol. (2007): 8(12):R264
    Kannan N, Wu J, Anand G, Shibu Y, Venter C, Taylor SS.
    ( PubMed )
  7. Structural and functional diversity of the microbial kinome.
    Plos Biol. (2007): 13;5(3)
    Kannan N, Taylor SS, Yufeng Z, Venter C, Manning G.
    ( PubMed )
  8. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
    PNAS. (2007): 104(4), 1272-7
    Kannan N, Haste N, Taylor SS, Neuwald AF.
    ( PubMed )
  9. Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component?
    J. Mol. Biol. (2005): 351, 956-972
    Kannan N, Neuwald AF.
    ( PubMed )
  10. Structural features associated with functional specificity of CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK and CK2alpha.
    Protein Sci. (2004): 13(8):100-128
    Kannan N, Neuwald AF.
    ( PubMed )
  11. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
    Protein Sci. (2005): 14(11):2871-9
    Wu J, Yang J, Kannan N, Madhusudhan, Xuong NH, Ten Eyck LF, Taylor SS.
    ( PubMed )
  12. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources.
    Methods. (2005): Jan; 35(1):90-114
    Andersen JN, Kannan N, Gergel J, Neuwald AF, Tonks NK.
    ( PubMed )
  13. Ran's C-terminal basic patch and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras and Ran GTPases.
    Genome Res. (2002): 13(4): 673-692
    Neuwald AF, Kannan N, Poleksic A, Hata N, Lu J.
    ( PubMed )
  14. Protein structure: Insights from graph theory.
    J. of Theor. and Comp. Chemistry. (2002): 1(1):187-212
    Vishveshwara S, Brinda KV, Kannan N.
    ( PDF )
  15. Analysis of homodimeric protein interfaces using graph spectral method.
    Protein Eng. (2002) 15(4): 265-77.
    Brinda KV, Kannan N, Vishveshwara S.
    ( PubMed )
  16. Clusters in alpha/beta barrel proteins: implications for protein structure and folding: a graph theoretical approach.
    Proteins. (2001): 43(2):103-12
    Kannan N, Selvaraj S, Gromiha MM, Vishveshwara S.
    ( PubMed )
  17. Stabilizing interactions in the dimer interface of alpha-subunit in E-coli RNA polymerase: A graph spectral and point mutation study.
    Protein Sci. (2001):10(1):46-54
    Kannan N, Chander P, Ghosh P, Vishveshwara S, Chatterji D.
    ( PubMed )
  18. Logos for amino-acid preferences in different backbone packing density regions of protein structural classes.
    Acta. D. (2000): 59(9):1156-65
    Kannan N, Schneider TD, Vishveshwara S.
    ( PubMed )
  19. Aromatic clusters: a determinant of thermal stability in thermophilic proteins.
    Protein Eng. (2000): 13(11): 753-61
    Kannan N, Vishveshwara S.
    ( PubMed )
  20. Identification of side-chain clusters in protein structures by a graph spectral method.
    J. Mol. Biol. (1999): 292(2):441-64
    Kannan N, Vishveshwara S.
    ( PubMed )